Hsiao Lab - UCSF

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Covers featuring our work and collaborations: 


A complete list of publications is available from the UCSF Profiles website: 

Hsiao lab publications - UCSF Profiles



Selected Recent Publications:

Hsiao, E.C., Boudignon, B.M., Chang, W.C., Bencsik, M., Peng, J., Nguyen, T.D., Manalac, C., Halloran, B.P., Conklin, B.R., and Nissenson, R.A. (2008). Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A 105(4), 1209-1214. PMCID: PMC2234117.

Ivey, K.N., Muth, A., J., A., King, F.W., Yeh, R.-F., Fish, J.E., Hsiao, E.C., Schwartz, R.J., Conklin, B.R., Bernstein, H.S., and Srivastava, D. (2008). MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell 2(3), 219-229. PMCID: PMC2293325.

Conklin, B.R., Hsiao, E.C., Claeysen, S., Dumuis, A., Srinivasan, S., Forsayeth, J.R., Guettier, J.M., Chang, W.C., Pei, Y., McCarthy, K.D., Nissenson, R.A., Wess, J., Bockaert, J., and Roth, B.L. (2008). Engineering GPCR signaling pathways with RASSLs. Nat Methods 5(8), 673-678. PMCID: PMC2703467.

Hsiao, E.C., Yoshinaga, Y., Nguyen, T.D., Musone, S.L., Kim, J., Swinton, P., Espineda, I., Manalac, C., DeJong, P., and Conklin, B.R. (2008). Marking embryonic stem cells using a 2A self-cleaving peptide: A NKX2-5 Emerald GFP BAC reporter. PLoS One 3(7), e2532. PMCID: PMC2430532.

Hsiao, E.C.*, Millard, S.M.*, Louie, A., Huang, Y., Conklin, B.R., and Nissenson, R.A. (2010). Ligand-mediated activation of an engineered Gs G-protein coupled receptor in osteoblasts increases trabecular bone formation. Mol Endocrinology. 24(3), 621-631. PMCID: PMC2840804.

Hsiao, E.C., Boudignon, B.M., Halloran, B.P., Nissenson, R.A., Conklin, B.R. (2010). Gs G-protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation. J Bone Miner Res. 25(3): 584-593. PMID: 20200944.

van Laake, L.W., Qian, L., Cheng, P., Huang, Y., Hsiao, E.C., Conklin, B.R., and Srivastava D. (2010). Reporter-Based Isolation of Induced Pluripotent Stem Cell- and Embryonic Stem Cell-Derived Cardiac Progenitors Reveals Limited Gene Expression Variance. Circulation Res. 107: 340-347. PMCID: PMC2919280.

Hsiao, E.C., Nguyen, T.D., Ng, J.K., Scott, M.J., Chang, W.C., Zahed, H., and Conklin, B.R. (2011). Constitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice. Stem Cell Research and Therapy 2(2), 11. PMCID: In process.

Kazakia, G.K., Speer, D., Shanbhag, S., Majumdar, S., Conklin, B.R., Nissenson, R.A., and Hsiao, E.C. (2011). Mineral Composition Is Altered by Osteoblast Expression of an Engineered Gs-Coupled Receptor. Calcified Tissue International 89: 10-20. PMCID: In process.

Schepers, K*, Hsiao, E.C.*, Garg, T., Scott, M.J., and Passegué, E. (2012). Activated Gs signaling in immature osteoblasts alters the hematopoietic stem cell niche in mice. Blood 120(17), 3425-3435. PMCID: PMC3482855. (*, equal contributors; Cover).

Schafer, A.L., Mumm, S., El-Sayed, I., McAlister, W.H., Horvai, A.E., Tom, A.M., Hsiao, E.C., Schaefer, F.V., Collins, M.T., Anderson, M.S., Whyte, M.P., and Shoback, D.M. (2013). Panostotic expansile bone disease with massive jaw tumor formation and a novel mutation in the signal peptide of RANK. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. (Cover)

Matsumoto, Y., Hayashi, Y., Schlieve, C.R., Ikeya, M., Kim, H., Nguyen, T.D., Sami, S., Baba, S., Barruet, E., Nasu, A., Asaka, I., Otsuka, T., Yamanaka, S., Conklin, B.R., Toguchida, J., and Hsiao, E.C. (2013). Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation. Orphanet journal of rare diseases 8(1), 190.

Akil, O.*, Hall-Glenn, F.*, Chang, J., Li, A., Chang, W., Lustig, L.R., Alliston, T., and Hsiao, E.C. (2014). Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia. PLoSOne 9(5):e94989. PMID: 24788917.

Barruet, E. and Hsiao E.C. (2014) Using Human Induced Pluripotent Stem Cells to Model Skeletal Diseases. Methods Mol Biol. 2014 Dec 31. [Epub ahead of print]

Orr, A.G., Hsiao, E.C., Wang, M.M., Ho, K., Kim, D.H., Wang, X., Guo, W., Kang, J., Yu, G-Q., Adame, A., Devidze, N., Dubal, D.B., Masliah, E., Conklin, B.R., and Mucke, L. (2015). Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory. Nature neuroscience 18(3), 423-434. PMCID: PMC4340760.

Wattanachanya, L., Wang, L., Millard, S.M., Lu, W.D., O'Carroll, D., Hsiao, E.C., Conklin, B.R., and Nissenson, R.A. (2015). Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive G-G protein signaling in osteoblasts. Experimental cell research. Exp Cell Res 333(2): 289-302 (2015). PMCID: PMC4408231.

Wang, L.*, Hsiao, E.C.*, Lieu, S., Scott, M., O'Carroll, D., Urrutia, A., Conklin, B.R., Colnot, C., and Nissenson, R.A. (2015). Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing. J Bone Miner Res 30(10), 1896-1904. (* equal contributors). PMID 25917236.

Cain, C.J., Gaborit, N., Lwin, W., Barruet, E., Ho, S., Bonnard, C., Hamamy, H., Shboul, M., Reversade, B., Kayserili, H., Bruneau, B.G., and Hsiao, E.C. (2016). Loss of Iroquois homeobox transcription factors 3 and 5 in osteoblasts disrupts cranial mineralization. Bone Rep 5, 86-95. PMID: 26901092.

Cain, C.J., Valencia, J.T., Ho, S., Jordan, K., Mattingly, A., Morales, B.M., and Hsiao, E.C. (2016). Increased Gs Signaling in Osteoblasts Reduces Bone Marrow and Whole-Body Adiposity in Male Mice. Endocrinology 157(4), 1481-1494.

Barruet, E., Morales, M., Lwin, W., White, M.P., Theodoris, C., Kim, H., Urrutia, A., Wong, S.A., Srivastava, D., and Hsiao, E.C. (2016). The human ACVR1 R206H mutation found in fibrodysplasia ossifcans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling. Stem Cell Res Ther. 7: 115.  PMID:  27530160

Hayashi, Y., Hsiao, E.C., Sami, S., Lancero, M., Schlieve, C.R., Nguyen, T., Yano, K., Nagahashi, A., Ikeya, M., Matsumoto, Y., Tomoda, K., Asaka, I., Toguchida, J., Conklin, B.R., and Yamanaka, S. (2016) Promotion of Reprogramming to Pluripotency by BMP-SMAD-ID against P16/INK4A-Dependent Senescence. In Press, Proceedings of the National Academy of Sciences USA.


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